comparison of sedation effectiveness of remifentanil-dexmedetomidine and remifentanil-midazolam combinations and their effects on postoperative cognitive functions in cystoscopies: a randomized clinical trial

نویسندگان

ayse hande arpacä± department of oral and maxillofacial, faculty of dentistry, ankara university and gazi university faculty of medicine, ankara, turkey

fusun bozkä±rlä± department of anaesthesiology and reanimation,2 gazi university faculty of medicine, ankara, turkey

چکیده

normal 0 false false false en-us x-none ar-sa background: t he aim of the study is to compare the effects of remifentanil/dexmedetomidine and remifentanil/midazolam combinations in monitored anesthesia care (mac) during cystoscopies. materials and methods: f orty patients who received remifentanil infusion of 0.05 m g kg -1 min -1 for cytoscopy procedure were randomized into two groups: e ither dexmedetomidine 1 m g kg -1 (group d) or midazolam 0.2 mg kg -1 h -1 (group m) was administered intravenously for the first 10 min. subsequently, anesthesia was maintained by using the bispectral index as a continuous infusion of dexmedetomidine (0.2-0.7 m g kg -1 h -1 ) or midazolam (0.05-0.15 mg kg -1 h -1 ). heart rate, mean arterial pressure, mini-mental state examination findings, levels of sedation andanalgesia, and the patient’s and surgeon’s satisfaction were recorded. results: s uccessful sedation and analgesia were achieved in all the patients. we were able to reach the target sedation level faster in group d ( p <0.0001). in group d, the cognitive functions were less affected than in group m ( p <0.0001). patient’s and surgeon’s satisfaction were significantly higher in group d. conclusion: t he targeted sedation levels were achieved in a shorter period with dexmedetomidine-remifentanil compared to midazolam-remifentanil. the dexmedetomidine-remifentanil combination was observed to affect the cognitive functions less than midazolam-remifentanil did with shorter recovery times. besides, patient’s and surgeon’s satisfaction rates were superior with dexmedetomidine-remifentanil. it was concluded that dexmedetomidine-remifentanil may be a combination of choice for monitored anesthesia care applications in outpatient surgical procedures of short duration.

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منابع مشابه

Comparison of sedation effectiveness of remifentanil-dexmedetomidine and remifentanil-midazolam combinations and their effects on postoperative cognitive functions in cystoscopies: A randomized clinical trial

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عنوان ژورنال:

journal of research in medical sciences

جلد ۱۸، شماره ۲، صفحات ۱۰۷-۰

کلمات کلیدی

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